Vocational education and training (VET) has a role to play in sustainable regional development. Through five regional case studies this research examines how well VET is tailoring supply to skill needs, how VET has become more flexible to obtain a better match between demand and supply, and whether partnerships have been linked to whole-of-government frameworks in ways which support sustainable regional development. The study concludes that successful relationships between VET and regional development require ongoing alignment both ways. Comprehensive regional frameworks could facilitate this co-development between VET and regional development.